Psychiatric Comorbidity Outweighs Headache Subtype As A Predictor Of Disability In Chronic Daily Headache: A Matched-Control Study.
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: Objective: Chronic daily headache (CDH) is a prevalent neuropsychiatric condition. We aimed to quantify concurrent Axis I psychiatric comorbidity and personality pathology in CDH versus matched controls and identify factors independently associated with headache-related disability. Method: This hospital-based matched-control study was conducted at a tertiary teaching hospital in Faridabad (Delhi-NCR), India. Seventy-five ICHD-3-confirmed CDH patients and 75 age- and sex-matched controls completed the Mini International Neuropsychiatric Interview (MINI v5.0), Millon Clinical Multiaxial Inventory-III (MCMI-III; personality, base rate ≥ 85), and Headache Impact Test-6 (HIT-6). Multivariable binary logistic regression identified independent cross-sectional associates of high disability (HIT-6 ≥ 56). STROBE guidelines were followed. Results: = 0.482). Conclusions: Psychiatric comorbidity was strongly and independently associated with disability in CDH, supporting integrated psychiatric screening. The exploratory Cluster A signal warrants replication in adequately powered prospective studies.
Source: PubMed Central
Authors: Vikram Singh, Sunil Goyal, Ankur Sachdeva
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7223379069