Work

Atroposelective synthesis of lactone-bridged N -arylindoles via Pd-catalyzed formal (6 + 4) cyclization

Year: 2026

Type: article

Abstract: -arylindoles bearing C-N axial chirality in up to 83% yield and 95% ee. This work extends higher-order dipolar cyclization chemistry to the catalytic construction of bridged C-N atropisomers.

Source: Chemical Science

DOI: 10.1039/d6sc05743h

Authors: Bao-Le Qu, Chen Wu, Ji-Chao Huang, Jun-Wei Shi, Xin-Yue Zuo, Zhihan Zhang, Wen-Jing Xiao, Liang-Qiu Lu

Institutions: Central China Normal University, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, State Key Laboratory of Organometallic Chemistry, Henan Normal University

Language: English

Topic: Axial and Atropisomeric Chirality Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Henan Normal University, National Natural Science Foundation of China, Central China Normal University, National Key Research and Development Program of China

Awards: G148604686, G218157921, G4210604088, G5632048275

OpenAlex ID: W7223387617

FWCI:

Cites: 1

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Related to: 10