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Office-based transperineal laser ablation for benign prostatic hyperplasia: Functional outcomes and predictors of clinical improvement

Year: 2026

Type: article

Abstract: Introduction: Transperineal laser ablation (TPLA) is an ultrasound-guided, office-based procedure for the treatment of benign prostatic hyperplasia (BPH). This study evaluates short-term functional outcomes following TPLA and identifies predictors of clinical improvement. Material and methods: ), and post-void residual (PVR). Intraoperative variables included ablation time and energy delivered. Pre- and post- treatement differences were assessed using the Wilcoxon signed rank test. Spearman correlation analysis evaluated predictors of improvement. Results: increased from 7.2 to 18.4 ml/s (p = 0.007). PVR decreased from 396.8 to 70.6 ml (p <0.001). Comorbidities included urinary tract infection or urosepsis history, hypertension, diabetes, hypercholesterolemia, and anticoagulation use. Postoperative complications included three patients with urinary retention requiring catheterization and one patient with urosepsis requiring hospitalization. Greater improvement correlated with higher baseline IPSS and PVR (p <0.001). Conclusions: Office-based TPLA produced significant short term functional improvement. Functional gains were comparable to those achieved with hospital based surgical interventions. Prospective, multicenter, randomized studies are warranted to further evaluate long term durability.

Source: Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication

DOI: 10.5173/ceju.2026.0090

Authors: Juan Varela, Rafael Aldaya Bourricaudy, Evren Cekin, Brian Miles, Victoria Yvonne Bird

Institutions: University of Florida, National Medical Association, Houston Methodist

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7204950341