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NFKB1 truncation–associated recurrent, sterile inflammation effectively treated with IL-1β blockade

Year: 2026

Type: article

Abstract: Recurrent, sterile inflammatory responses to surgery and trauma in a patient with a heterozygous, truncating NFKB1 variant are described. This case illustrates the autoinflammatory phenotype of truncating NFKB1 variants and highlights the prospect of a targeted, personalized immunomodulatory therapy.

Source: Journal of Human Immunity

DOI: 10.70962/jhi.20260157

Authors: Kevin S. Ackerman, Isabel F. Armendi, Jay J. Mehta, Neil Romberg

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Jeffrey Modell Foundation, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases