Work

Potential Association of BRCA Mutation and Lymphocytic Lobulitis

Year: 2026

Type: article

Abstract: Lymphocytic lobulitis (LL) is a rare fibroinflammatory breast lesion historically associated with long-standing Type 1 diabetes mellitus and autoimmune conditions. Recent evidence suggests possible links between LL and hereditary breast cancer syndromes, particularly BRCA mutations. We present the case of a BRCA1 mutation carrier who developed bilateral lymphocytic lobulitis with B-cell predominance, discuss its clinicopathologic features, and review current literature on the intersection of autoimmune, metabolic, and genetic risk pathways.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.73798

Authors: Parul Garg, Sena Park, Femi E. Ayeni, Senarath Edirimanne

Institutions: Nepean Hospital, The University of Sydney

Language: English

Topic: Breast Lesions and Carcinomas

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820