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Contralateral atypical femoral fracture following a single dose of denosumab after incomplete teriparatide therapy in a patient with long-term bisphosphonate exposure: A case report

Year: 2026

Type: article

Abstract: Atypical femoral fractures (AFFs) are rare but serious complications of prolonged antiresorptive therapy. While bisphosphonate-associated AFF is well documented, the risk associated with sequential teriparatide and antiresorptive therapy remains poorly characterized. This case demonstrates that contralateral impending AFF can develop after a single dose of denosumab in a bisphosphonate-pretreated patient, despite confirmed radiological normality at the time of the index fracture. Negative contralateral imaging should not provide reassurance in high-risk patients, and vigilance is warranted when considering antiresorptive therapy transitions following incomplete anabolic treatment.

Source: Bone Reports

DOI: 10.1016/j.bonr.2026.101965

Author: Dong-Hoon Lee

Institution: Chung-Ang University Gwangmyeong Hospital

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,540