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A Pilot Study of Linezolid for Early Syphilis Treatment

Year: 2026

Type: article

Study design: Clinical Trial

Abstract: In a study of oral linezolid among 18 patients with early syphilis, 15 showed adequate serological response by 6 months. Among 6 patients treated with benzathine penicillin G, 5 showed adequate serological response. There were no serious adverse events. Linezolid shows promise for the treatment of early syphilis.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofag690

Authors: Ryan M Nguyen, Chrysovalantis Stafylis, Kelika A Konda, E Michael Reyes-Diaz, Kori Keith, Keith Stokes, Catherine Creticos, Candice J McNeil, Philip A Chan, James B Brock, Byron Buck, Ebony Warren, Rica M Abbott, Jennifer L Nall, Peter Salhaney, Takila Keys, Jeffrey D Klausner

Institutions: University of Southern California, Universidad Peruana Cayetano Heredia, Howard Brown Health Center, Wake Forest University Health Sciences, Wake Forest University, University of Mississippi Medical Center

Language: English

Topic: Syphilis Diagnosis and Treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

OpenAlex ID: W7223469600

FWCI:

Cites: 9

Cited by:

Related to: 10