Sobrepeso y obesidad materna como factores de riesgo independientes para el desarrollo de preeclampsia: revisión sistemática
Year: 2026
Type: article
Study design: Systematic Review
Abstract: DOI: https://doi.org/10.46296/gt.v9i18.0405 Abstract Introduction: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, and maternal excess weight is a potentially modifiable risk factor. The aim was to evaluate maternal overweight and obesity as independent risk factors for preeclampsia and to analyze gestational weight gain according to pre-pregnancy body mass index (BMI). Methodology: Systematic review with narrative synthesis, following PRISMA 2020, in PubMed/MEDLINE, SciELO and LILACS (2021–2026); quality was appraised with CASP and JBI tools. Results: Of 1068 records, 28 studies were included (five meta-analyses and 23 primary studies), of high quality in 11, moderate in 14 and low in three. Compared with normal weight, meta-analyses estimated ORs of 1.70 to 2.15 for overweight and 2.82 to 3.89 for obesity, with a dose-response gradient. The association persisted after adjustment for confounders (adjusted ORs 2.15 to 4.34) and in Mendelian randomization (OR 1.47 per standard deviation of BMI). Weight gain above recommendations increased the risk (OR 1.85), with lower rate thresholds as BMI increased (0.54, 0.38 and 0.25 kg/week). Discussion: Adjusted estimates and genetic evidence support the independence of the effect, although several meta-analyses used crude data and Latin American evidence is scarce. Conclusions: Maternal overweight and obesity are independent risk factors for preeclampsia, and the gestational weight gain curve, interpreted according to pre-pregnancy BMI, is a useful tool for prevention in prenatal care. Keywords: preeclampsia; maternal obesity; overweight; body mass index; gestational weight gain; risk factors; systematic review.
Institution: Universidad Tecnica de Machala
Language: Spanish
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7223522914