Work

Synthesis, Characterization, and Antibacterial Efficacy of Cu-ZIF-8: In Vitro Study of Multidrug-Resistant Gram-Positive and Gram-Negative Bacteria

Year: 2026

Type: article

Abstract: Recently, Staphylococcus aureus and Pseudomonas aeruginosa have become multidrug-resistant (MDR) and produce many virulence factors, posing a health risk. Therefore, addressing knowledge gaps and finding solutions to the challenge caused by bacteria's increased resistance to multiple antibiotics is an urgent need. To address this risk, we aim to synthesize new nanoparticles with long-lasting, safe effects and low toxicity. Metal–organic frameworks (MOFs) are promising materials with high efficiency in inhibiting or killing MDR bacteria. In this investigation, we successfully synthesized copper-doped ZIF-8 (Cu-ZIF-8) nanocomposites using the solvothermal method. Its characteristics were studied using techniques like SEM, FTIR, EDX, and XRD. The Cu-ZIF-8-MOF exhibited high antibacterial efficacy against S. aureus (Gram-positive) and P. aeruginosa (Gram-negative), with concentrations of 12.5, 25, 50, and 100 μg/mL showing high efficiency against P. aeruginosa. In contrast, it was less effective against S. aureus. These results open up wide prospects for the application of the Cu-ZIF-8-MOF antimicrobial agent.

Source: HAYATI Journal of Biosciences

DOI: 10.4308/hjb.33.6.1541-1551

Authors: Nibras Saleh Ghafil Al Tameemi, Iman Fadhil Abdul-Husin, Raid Razzaq Ojaimi, Zainab Zaidan Mutashar

Institution: Al-Qasim Green University

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250