KASID Guidelines for the Medical Treatment of Ulcerative Colitis: 2026
Year: 2026
Type: article
Abstract: Ulcerative colitis (UC) is a chronic immune-mediated inflammatory bowel disease with an expanding therapeutic landscape and increasing clinical complexity. This guideline was developed by the Korean Association for the Study of Intestinal Diseases (KASID) to provide updated, evidence-based recommendations for the medical management of adult patients with UC in Korea. Guideline development used the GRADE-ADOLOPMENT approach, with source guidelines appraised using AGREE II. Key questions were formulated using the PICO framework, source guidelines and consensus documents published from 2017 through 2025 were appraised, and targeted literature searches covering January 2020 through April 2026 were conducted in PubMed, Embase, the Cochrane Library, and KoreaMed. The guideline addresses induction and maintenance therapy for mild-to-moderate and moderate-to-severe UC, management of acute severe UC, indications for surgery, use of biosimilars and subcutaneous formulations, and treatment optimization and sequencing. Recommendations were formulated based on structured evidence review and Evidence-to-Decision considerations, and were finalized through a modified Delphi consensus process and external review. The final recommendations emphasize objective disease control, individualized treatment selection, timely escalation or surgery in acute severe UC, and shared decision-making based on efficacy, safety, comorbidities, prior treatment exposure, patient preference, drug accessibility, and the Korean healthcare context. This guideline is intended to support consistent, practical, and patient-centered care and to improve long-term outcomes for adults with UC.
DOI: 10.4166/kjg.2026.091
Authors: Dong Hyun Kim, Seung Min Hong, Seung Yong Shin, June Hwa Bae, Eun Mi Song, Ji Eun Kim, Young Joo Yang, Jiyoung Yoon, Sang-Bum Kang, Eun Soo Kim, Seong-Eun Kim, Seong-Jung Kim, Jun Lee, Soo-Young Na, Soo Jung Park, Sang Hyoung Park, Myung Ha Kim, Miyoung Choi, Jong Lyul Lee, Se-Jin Baek, Won Moon, Sung-Ae Jung
Institutions: Chonnam National University, Pusan National University Hospital, Pusan National University, Chung-Ang University Hospital, Chung-Ang University Healthcare System, Chung-Ang University, Daegu Catholic University, Daegu Catholic University Medical Center, Ewha Womans University, Ewha Womans University Medical Center, Ewha Womans University Seoul Hospital, Samsung Medical Center, Sungkyunkwan University, Hallym University, Hallym University Chuncheon Sacred Heart Hospital, Kangdong Sacred Heart Hospital, The Catholic University of Korea Daejeon St. Mary's Hospital, Catholic University of Korea, Kyungpook National University, Chosun University, Asan Medical Center, University of Ulsan, The Catholic University of Korea Incheon St. Mary's Hospital, Yonsei University, Yonsei University Health System, National Evidenc- based healthcare Collaborating Agency, Korea University, Kosin University
Language: Korean
Topic: Inflammatory Bowel Disease
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $7
OpenAlex ID: W7223553189