Clinico-morphological parallels in lung and kidney involvement in patients with Goodpasture syndrome (clinical cases)
Year: 2026
Type: article
Study design: Case Report
Abstract: The article presents three clinical cases of Goodpasture syndrome (GS) in two men and one woman, as well as an analytical review of the literature. The purpose of the work: to familiarize practitioners with the problem of diagnosing and treating GS and, based on the presentation of their own clinical observations, to focus the attention of general practitioners, nephrologists, therapists, pulmonologists on the problem of the difficulty of establishing a diagnosis and the features of challenges in managing patients with this pathology. Goodpasture syndrome is currently considered an immune complex vasculitis associated with the presence of antibodies to the basement membrane of the capillaries of the glomeruli of the kidneys and alveoli in the circulation or in situ. The etiology of GS is not known for certain, the pathogenesis is complex and not fully understood. The clinical manifestations of GS syndrome are quite polymorphic, but are usually characterized by increasing renal failure and pulmonary hemorrhage. The main diagnostic methods are immunological studies with the determination of antibodies to the glomerular basement membrane and morphological confirmation of the diagnosis after lung and kidney biopsy with histological examination. The presented descriptions of case histories indicate that the disease had an atypical onset and this allowed the diagnosis of GS to be made only at the stage of inevitable complications. Rapid progression with the development of terminal renal failure and pulmonary hemorrhage led to the death of the patients. The full implementation of the recommended therapy was postponed due to the severity of clinical manifestations and the development of complications. The article justifies the need to involve a multidisciplinary team of doctors in order to establish a diagnosis as early as possible and prescribe appropriate therapy in full, which is a prerequisite for postponing inevitable complications and, in some cases, regression of the disease.
Source: Medicni perspektivi
Institution: Dnipro State Medical University
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7223569636