Prognostic impact of the preoperative Naples prognostic score on overall and progression-free survival in surgically treated oral squamous cell carcinoma: A retrospective cohort study from a Taiwanese medical center.
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background/purpose: Systemic inflammation and nutritional status are key determinants of cancer progression and survival. The Naples prognostic score (NPS), integrating nutritional and inflammatory biomarkers, has shown prognostic value in cancers, however its significance in oral squamous cell carcinoma (OSCC) remains unclear. This study evaluated the prognostic value of NPS in patients with OSCC undergoing curative surgery. Materials and methods: This retrospective cohort study included 334 patients with OSCC who underwent surgery at a Taiwanese medical center between 2002 and 2015. Preoperative serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio were used to calculate NPS. Patients were categorized into three groups: Group 0 (score=0), Group 1 (score = 1-2), and Group 2 (score = 3-4). Five-year overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meier methods and log-rank tests. Multivariate Cox proportional hazards regression was performed to identify independent prognostic factors. Results: =0.038). The prognostic significance of NPS persisted after adjustment for clinicopathological variables, including surgical margin status, depth of invasion, and extranodal extension. Conclusion: NPS is an independent prognostic indicator in patients with OSCC undergoing surgery. Incorporating NPS into preoperative assessment may improve risk stratification and support treatment planning.
Source: PubMed Central
Institutions: Tri-Service General Hospital, National Defense Medical Center
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Tri-Service General Hospital
OpenAlex ID: W7223571691