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Quantitative Sciences in the Model‐Informed Era: From Parallel Functions to a Shared Decision System

Year: 2026

Type: article

Abstract: Model-informed drug development increasingly depends on collaboration among clinical pharmacology, statistics, pharmacometrics, and quantitative systems pharmacology. Yet functional silos, distinct leadership structures, and divergent goals can reduce collaboration to late, parallel deliverables that constrain decision architecture. This Perspective defines a shared decision system as an operating model in which quantitative and clinical disciplines jointly define the question, context of use, evidentiary role, uncertainty standards, and accountability for model-informed evidence.

Source: Clinical Pharmacology & Therapeutics

DOI: 10.1002/cpt.70531

Authors: Avery McIntosh, Mohamed Elmeliegy, Jeffrey P. Palmer, Nikolaos Tsamandouras, Vaishali Sahasrabudhe, Blerta Shtylla

Institution: Pfizer (United States)

Language: English

Topic: Pharmaceutical studies and practices

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

OpenAlex ID: W7223575564

FWCI:

Cites: 6

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Related to: 10