Work

Clarifying Problems in the Synthetic Pathway Towards Methylene‐Type Levodopa Acylals as Potential Prodrugs

Year: 2026

Type: review

Abstract: Here, we report a practical synthetic pathway towards levodopa (l-DOPA) acylals with a special emphasis on problems occurring during preparation, low yields or unmanageable side reactions, and how to circumvent them. The key step can be performed rapidly by microwave irradiation in a green chemistry manner. Final compounds can be achieved after deprotection approaches but exhibit inadequate properties in terms of stability, thwarting the adaptation of the double ester concept discussed here to the important active pharmaceutical ingredient levodopa. However, a future outlook is provided, discussing potential structural and chemical changes for stable levodopa acylals.

Source: Archiv der Pharmazie

DOI: 10.1002/ardp.70376

Authors: Tobias Keydel, Yann Theele, Andreas Link

Institutions: Universitätsmedizin Rostock, University of Bonn, Universität Greifswald

Language: English

Topic: Microwave-Assisted Synthesis and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,300

Funder: Deutsche Forschungsgemeinschaft