Work

From Cellular Origin to Clinical Recurrence: Rethinking Tumor Boundaries in Isocitrate Dehydrogenase-Mutant Gliomas

Year: 2026

Type: review

Abstract: mutation-bearing cells within histologically and radiologically normal peritumoral cortex, suggesting that the earliest stages of gliomagenesis may extend beyond the conventionally defined tumor margin. This observation suggests that these mutation-bearing cortical cells may contribute to tumor recurrence even after gross total resection and supports the potential value of early therapeutic intervention targeting these latent cells, such as with IDH inhibitors, to delay disease progression. Collectively, these insights suggest that IDH-mutant gliomas may be better understood as a spatially extended biological process rather than a strictly localized lesion. A more integrated approach that combines precise surgical techniques with molecularly informed therapies may improve long-term disease control.

Source: Brain Tumor Research and Treatment

DOI: 10.14791/btrt.2026.0018

Author: Jung Won Park

Institutions: Korea Advanced Institute of Science and Technology, Catholic University of Korea

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Korea Health Industry Development Institute, National Research Foundation of Korea, Ministry of Science and ICT, South Korea