Work

Optimization and Characterization of Serum of Red Onion Skin Extract and Antioxidant Activity

Year: 2026

Type: article

Abstract: Red onion (Allium cepa L.) skin is enriched with flavonoids, steroids, and phenolic compounds, which possess the potential to promote hair growth. The present investigation sought to optimize gelling agent concentrations within hair serum formulations incorporating red onion peel extract (Allium cepa L.) for its antioxidant properties. Formula optimization was executed employing the Regular Two-Level Factorial Design methodology utilizing Design Expert® 13 software. Two independent variables were examined: carbomer 940 concentration ranging from 0.1–0.3% and sodium alginate concentration ranging from 0.5–1%. Through factorial analysis of physical properties, formula 2 emerged as optimal, containing carbomer 940 at 0.3% and sodium alginate at 1%. The resultant formulation demonstrated the following physicochemical characteristics: pH of 6.14±0.01, viscosity of 854.35±12.87 cP, spreadability of 7.26±0.70 cm, adhesiveness of 8.02±0.19 cm, and additional adhesion metrics of 8.69±0.27 cm, 4.17±0.23 s, and 3.35±0.26 s. Accelerated stability assessment via cycling protocols revealed preservation of organoleptic integrity, absence of phase separation or syneresis, and constancy in pH and viscosity parameters. The optimal red onion peel extract serum formulation demonstrated an IC50 value of 84.00 ppm, reflecting substantial antioxidant capacity and considerable promise for further pharmaceutical development as an antioxidant agent.

Source: Journal of Food and Pharmaceutical Sciences

DOI: 10.22146/jfps.28645

Authors: Dina Permata Wijaya, Fakhira Nabila, Shaum Shiyan, Herlina Herlina, Viva Starlista

Institution: Sriwijaya University

Language: English

Topic: Garlic and Onion Studies

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Zero hunger

Open Access status: diamond

Funder: Universitas Sriwijaya