Membrane state may tune calcium's restraint of renin secretion
Year: 2026
Type: article
Abstract: This Mini-Review examines the hypothesis that membrane organisation in a defined juxtaglomerular compartment conditions the strength and timing of calcium-mediated restraint of renin secretion. Within the membrane-encoded chemosensory system (MECS) framework, cholesterol accessibility, lipid organisation or membrane mechanics could influence calcium recruitment, calcium-dependent cyclic AMP suppression or downstream secretion. If inhibitory coupling is affected, comparable relevant local calcium dynamics could produce different active-renin responses. The manuscript develops complementary predictions for pressure dependence and active-renin recovery, which may change independently. Similar initial suppression during a pressure pulse could precede different recovery after pressure returns to its starting value, potentially altering cumulative active-renin output. A separate reversibility prediction is that changing a measured membrane property should alter the affected signalling contribution and renin response, while restoring that property before a matched challenge should recover both. Cannabinoid, olfactory and TRPV4-associated routes are examined as candidate implementations, including a hypothetical arrangement involving vascular mechanics and a separate mouse Olfr78 metabolite input. The review distinguishes established experimental precedents from proposed mechanisms. Native membrane mediation and combined route operation remain untested in the juxtaglomerular apparatus. Potential consequences for renin–angiotensin–aldosterone signalling and clinical responses require independent validation, including human evidence.
Author: Yarar, Erhan
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7223663074