Fractionation, Structural Characterization and In Vitro α-Amylase and α-Glucosidase Inhibitory Activities of Polysaccharides Derived from Lycium barbarum L.
Year: 2026
Type: article
Abstract: Polysaccharides have attracted extensive attention due to their pharmacological activities, such as regulating depression, antitumor, hypoglycemic and lipid-lowering effects, and regulating intestinal flora. In this study, four crude polysaccharide fractions were separated and prepared from Lycium barbarum L., named LICP007, LICP008, LICP009 and LICP010. With hypoglycemic activity in vitro, LICP007 with a better hypoglycemic effect was selected for further separation and purification, and one neutral polysaccharide (LICP007-N1) and two acidic polysaccharides (LICP007-S2 and LICP007-S5) were obtained by DEAE-52 and Sephadex G-200 gel electrophoresis. Among them, LICP007-S5 showed the best inhibitory activity against α-amylase and α-glucosidase. Studies on physical and chemical properties show that LICP007-S5 was indeed very different from LICP007-N1 and LICP007-S2 in molecular weight distribution, monosaccharide composition, morphology and so on. These findings provide comparative information on the structure and biological activity of different Lycium barbarum polysaccharides and highlight their potential as hypoglycemic agents in functional foods.
Source: Molecules
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,258
OpenAlex ID: W7207808898