Extraction and Identification of the Sea Cucumber Holothuria Parva, Secondary Metabolites and Investigation of Their Potential Anti-SARS-Cov-2 Activities Using Molecular Docking.
Year: 2026
Type: article
Abstract: Background: ) of SARS-CoV-2 are key targets for developing and introducing molecules that act as anti-SARS-CoV-2 replication agents, whether these molecules are derived from natural sources or synthesized. Objectives: This study aimed to extract and identify phenolic compounds and saponins from the dominant species of sea cucumber (Holothuroidae) found on selected beaches in Bushehr Province, and subsequently investigate their potential anti-SARS-CoV-2 properties using molecular docking. Materials and Methods: . Also, we confirmed the presence of phenolic compounds and saponins using high-performance thin-layer chromatography (HPTLC). Additionally, we identified the phenolic compounds through liquid chromatography-mass spectrometry (LC-MS) analysis. The molecular docking analysis (using AutoDockVina software) of our compounds on six targets, which play significant roles in the treatment of COVID-19, was conducted in this research. Results: (especially phenolic compounds and saponins), we conducted a series of molecular docking studies on the mentioned targets and achieved satisfactory results. Conclusion: .
Source: PubMed Central
Authors: Maryam Roshani, Bita Archangi, Faede Amini
Language: English
Subfield: Aquatic Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7223666190