Work

Semisyntheses of Aspercyclicins A and B via Isobenzofuran Cycloaddition

Year: 2026

Type: preprint

Abstract: The recently isolated aspercyclicins A and B from Aspergillus sp. LI2020F001 represent a chimeric scaffold derived from crosstalk of two biosynthetic pathways. These natural products display cytotoxicity against cancer cell lines and potently activate immunogenic cell death (ICD). Herein, we report methodology development for biomimetic [4+2] cycloadditions involving an in situ generated isobenzofuran (IBF) leading to the semisyntheses of aspercyclicins A and B from the fungal-derived natural product (+)-geodin.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15011019/v1

Authors: Edgar S. Villa, James McNeely, Hanna R. Warinner, John A. Porco

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7223672017

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