Ruthenium(II) Carbosilane Dendrimers With Aliphatic Polyamine Ligands for In Vivo Antimelanoma Activity

Year: 2026

Type: article

Abstract: Metastatic melanoma remains a major therapeutic challenge due to the limited efficacy of current systemic treatments, which is motivating the development of alternative drug delivery strategies. Herein, we report the synthesis and characterization of carbosilane metallodendrimers functionalized with Ru(II) complexes bearing norspermidine-derived ligands and evaluate their anticancer activity using malignant melanoma as a model of aggressive cancer. In vitro and in vivo studies demonstrate that these macromolecular systems exhibit enhanced antitumour activity compared with their mononuclear ruthenium counterparts. Notably, the second-generation metallodendrimer produced a remarkable antitumour response in vivo, reducing tumour mass by more than 65% after single administration. These findings indicate that the biological performance of these Ru(II)-based systems depends not only on the presence of multiple metal centres but also on the nanoscale dendritic architecture, highlighting the potential of metallodendrimers as macromolecular platforms for anticancer therapy.

Source: Bioinorganic Chemistry and Applications

DOI: 10.1155/bca/4574339

Authors: Yoel Garrosa-Miró, Lorena García Hevia, Mónica L. Fanarraga, Paula Ortega, Francisco Javier de la Mata

Institutions: Universidad de Alcalá, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Instituto Ramón y Cajal de Investigación Sanitaria, Universidad de Cantabria, Instituto de Investigación Marqués de Valdecilla

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,630

Funders: Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades, Ministerio de Ciencia e Innovación, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Universidad de Alcalá, Junta de Comunidades de Castilla-La Mancha, Instituto de Salud Carlos III, European Regional Development Fund, Agencia Estatal de Investigación

OpenAlex ID: W7223683051