Work

Comparative outcomes of primary percutaneous coronary intervention and pharmacoinvasive strategies in patients with ST-elevation myocardial infarction in palestine: a multicenter retrospective cohort study

Year: 2026

Type: article

Abstract: Background Myocardial infarction (MI) is among the most diagnosed cardiological diseases in the whole world and in Palestine, and is managed mainly by percutaneous coronary intervention (PCI), or in addition of tissue plasminogen activator (tPA), i.e., pharmacoinvasive approach. The aim of the current study is to identify the most common postoperative complications, and compare differences according to demographic factors, in both approaches in two tertiary centers in West Bank – Palestine. Methodology A retrospective cohort design was utilized on a randomized sample of 160 adult (30–75 years old) patients who were admitted to intensive care cardiology departments of Palestine Medical complex (for pharmacoinvasive approach) and An-Najah National University Hospital (for PCI approach). The researcher used a data sheet that was developed based on previous literature, and data were analyzed using SPSS software. Results Patients who underwent PCI (n = 82, 51.2%) were significantly older (mean = 59.8 ± 9.7 vs 56.2 ± 12.7) than pharmacoinvasive (n = 78, 48.8%), with more radial site of insertion use (95.1% vs. 15.4%), and no significant difference in MI location. PCI patients showed more significant decrease in some laboratory tests and heart rate, with more significant increase in troponin-I, compared to pharmacoinvasive patients (p-value < 0.05) between pre- and post-operative phases. Most postoperative complications, and mortality rate, were significantly higher among pharmacoinvasive patients (p-value < 0.05). Lastly, significantly more postoperative complications were found among patients with dyslipidemia, valve regurgitation and cardiac hypokinesia. Conclusion Patients who were treated with pharmacoinvasive approach showed higher postoperative complications and 30-day mortality rate. More research is needed in this area of cardiology management in Palestine. A prospective design is also recommended to be conducted for this topic in the future research.

Source: Journal of Cardiothoracic Surgery

DOI: 10.1186/s13019-026-04756-9