Work

HPV prevalence and genotype distribution in rare cervical adenocarcinoma subtypes: A 10-year retrospective cohort study from Brazil

Year: 2026

Type: article

Abstract: Objectives: This study aimed primarily to determine human papillomavirus prevalence and genotype distribution in rare cervical adenocarcinoma subtypes. Secondary objectives were to evaluate associations between human papillomavirus status, clinicopathological characteristics, and survival outcomes. Methods: This retrospective cohort included patients with rare cervical adenocarcinoma subtypes treated at the Brazilian National Cancer Institute between 2011 and 2021. Human papillomavirus deoxyribonucleic acid (DNA) detection and genotyping were performed in histopathological samples. Results: Among 107 patients, the median age at diagnosis was 44.00 years (interquartile range 37.00, 52.50). Tumor samples from 88 patients were available for human papillomavirus DNA analysis, of which 78 (88.64%) were positive. Genotype 16 (69.23%) was the predominant genotype. Non-mucinous adenocarcinomas were associated with poorer overall survival (HR 4.77; 95% CI 1.78, 12.76), whereas human papillomavirus status was not significantly associated with survival outcomes. Conclusion: Human papillomavirus DNA positivity was high among rare cervical adenocarcinoma subtypes. Mucinous variants had significantly better overall survival than non-mucinous subtypes. These findings should be interpreted cautiously given the retrospective, single-center design and small number of human papillomavirus-negative cases, which limited statistical power for survival comparisons.

Source: Preventive Medicine Reports

DOI: 10.1016/j.pmedr.2026.103679