Work

Laryngeal cryptococcosis with clinical failure to fluconazole in a patient with common variable immunodeficiency: A treatment dilemma

Year: 2026

Type: article

Abstract: ABSTRACT We describe the case of a 57-year-old female with chronic hoarseness and cough whose laryngeal exam revealed chronic laryngitis with exudates. She failed multiple courses of fluconazole for presumed laryngeal candidiasis. Pathology demonstrated laryngeal cryptococcosis, and sputum cultures grew Cryptococcus neoformans with an elevated fluconazole MIC. Immunological evaluation led to the diagnosis of common variable immunodeficiency. After complications with alternative antifungals, the patient responded favorably to isavuconazole and intravenous immunoglobulin replacement.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2026.100831

Authors: Rija Binte Rehan Alvi, Ross M. Mayerhoff, Eloy E. Ordaya

Institution: Henry Ford Hospital

Language: English

Topic: Fungal Infections and Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650