默认模式网络、熵脑与神经振荡:从 5-HT2A 受体动力学、松果体方解石微晶到禅定注意力的计算神经科学 | The Default Mode Network, the Entropic Brain and Neural Oscillations: 5-HT2A Receptor Kinetics, Pineal Calcite Microcrystals and the Computational Neuroscience of Meditative Attention
Year: 2026
Type: book
Abstract: When nothing is asked of it, the brain does not go quiet. This book uses computational neuroscience, pharmacology and information theory to study the default mode network and the rhythms and molecules that change it: the brain's energy budget at rest (about 2 % of body mass, 20 % of energy, with tasks adding under 5 %) and network hubs analysed with graph theory (removing the posterior cingulate cuts global efficiency by about a fifth); the Kuramoto model of coupled oscillators and its synchronisation transition (critical coupling Kc = 2γ, simulation matching theory); 5-HT2A receptor binding with a dimensionless Hill–Langmuir equation, Lempel–Ziv complexity and Shannon entropy showing that "more entropy" is not "better", and a review of the imaging studies of Carhart-Harris and colleagues, the entropic brain hypothesis and the risks and limits of the clinical trials; the evidence that experienced meditators deactivate the default network while coupling it more strongly to control networks, with a mind-wandering Markov chain and a stability model; melatonin synthesis and its suppression by light, and why the calcite microcrystals of the pineal gland are not piezoelectric in bulk and resonate millions of times above any brain rhythm; and the state of the evidence on 40 Hz light and sound stimulation and on binaural beats. The eight chapters are read beside the Diamond Sūtra, the Platform Sūtra and the Secret of the Golden Flower, and end with a four-week sitting and mind-wandering log and a pre-registered randomised crossover trial comparing breath-focused listening with binaural beats (64 completers, with the decision rule written as code). Marked boxes separate published evidence, runnable Python calculations (28, all checked), classical sources and the author's hypotheses. Legal and medical notice: this book is not medical or legal advice; psilocybin and related tryptamines are strictly controlled in Malaysia (Dangerous Drugs Act 1952), China and most other jurisdictions, and the book does not advise obtaining or using any controlled substance and gives no doses. 不要求大脑做任何事时,它并不安静。本书用计算神经科学、药理学与信息论研究「默认模式网络」与改变它的节律和分子:大脑静息时的能量预算(约占体重 2%、耗能 20%,任务只增加不到 5%),以及用图论计算的网络枢纽(移除后扣带回使全局效率下降约五分之一);库拉莫托耦合振子模型与同步相变(临界耦合 Kc = 2γ,模拟与理论吻合);用无量纲 Hill–Langmuir 方程描述 5-HT2A 受体结合,用 Lempel–Ziv 复杂度与香农熵说明「熵更高不等于更好」,并综述卡哈特-哈里斯等人的影像研究与「熵脑」假说及临床试验的风险与局限;资深禅修者默认网络去激活与控制网络耦合增强的证据,以及走神—觉察马尔可夫链和稳定性模型;松果体的褪黑素合成与光抑制模型,以及方解石微晶为何在块体上不具压电性、其声学谐振为何远高于脑节律;40 Hz 声光刺激与双耳节拍的证据现状。 八章与《金刚经》「应无所住而生其心」、《六祖坛经》「无念为宗」、《太乙金华宗旨》「回光」并读;最后给出四周静坐与走神捕捉记录表,以及一项比较专注听息与双耳节拍的预注册随机交叉试验(64 人完成,判定规则写成代码)。书中以标注框区分已发表的证据、可运行的 Python 计算(28 段,全部核对)、原典与作者的假说。法律与医学声明:本书不是医疗或法律建议;裸盖菇素等色胺类物质在马来西亚(《1952 年危险毒品法令》)、中国及绝大多数司法辖区受严格管制,本书不以任何形式建议获取或使用任何受管制物质,不提供任何剂量。 Disclosure. The author and his group operate websites on singing (vocal.guru and singingasia.com, where the author teaches a listening method mentioned in the book), on frequency and resonance (sacredcubit.com and tensorcoil.com) and on health topics (ketohackers.com and nadplusnadplus.com), and so have a commercial interest in some of the subjects of this book. The book does not promote any product, course or supplement; all the code and the study protocol are published openly for anyone to check. Note on writing. The text, boxes and code were drafted with an AI writing tool from the author's title, framework and notes; the author is responsible for reviewing and revising them and for checking every source. SHA-256 checksums dmn-neural-oscillations_bilingual_v1.0.0.pdf: c0984b9a4559518f54e90973e03e441f25f9cb811f845f1be9732187c7bbbc37 dmn-neural-oscillations_en_v1.0.0.pdf: 0a3368b5cd05585681ef3ebd07733fd32b9aac7fdc5fc7e695d81da2ab0ce117 dmn-neural-oscillations_zh_v1.0.0.pdf: daf8638cd58f7ba4ec45bed062c829a58ec54811d71c43b334fd51c8db6040c5 dmn-neural-oscillations_bilingual_v1.0.0.epub: aa1eb119e162ca543f3c305483e967e6aca3e05a6f0581c9f7606faaf4d55bce dmn-neural-oscillations_en_v1.0.0.epub: 017e4a4d068e8a0ac5685ff73ddf048aa1349267bdbd0b33bdde847941a7b8ab dmn-neural-oscillations_zh_v1.0.0.epub: 76b442d49ad07a52e3e561391a8823c8f041da8943c486ff975a8035482cf08a
Author: Fan, Yafu
Language: Chinese
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7223784992