[Efficacy evaluation of extracellular vesicle drug delivery system in orthotopic intravesical perfusion for bladder cancer].
Year: 2026
Type: article
Abstract: experiments using orthotopic bladder cancer mouse models further proved that EVs@THP possessed better tissue penetration and intravesical retention after perfusion, with significantly superior antitumor efficacy to free THP. MB49 cell-derived EVs are promising delivery carriers for THP. The EVs@THP system with good biocompatibility and targeting ability can effectively improve the outcome of bladder cancer intravesical chemotherapy, providing experimental evidence for the development and transformation of novel intravesical therapeutic regimens.
Source: PubMed Central
Authors: Mei Zheng, Xin Gao, Juan Liu, Lulu Tan, Yawei Song
Institution: Guangzhou University of Chinese Medicine
Language: Chinese
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7223808029