[Association between depressive symptoms and renal hyperfiltration in middle-aged and older adults].
Year: 2026
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To investigate the associations of depressive symptoms and depressive episodes with renal hyperfiltration (RHF) in middle-aged and older adults. METHODS: , urine albumin-to-creatinine ratio ≥30 mg/g, malignant tumors, incomplete depression questionnaire data, or antidepressant use, the participants were assessed for depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and categorized in <5, 5-9, and ≥10 groups. Depressive episode status was also evaluated. RHF was defined as residuals above the 95th percentile from a regression model of log-transformed eGFR adjusted for age, sex, height, weight, hypertension, and diabetes. The associations of depressive status with RHF and the dose-response relationship between PHQ-9 total score and RHF risk were assessed using multivariable logistic regression and restricted cubic spline analysis, respectively. Random forest, SHAP, and Boruta were used for exploratory analyses. RESULTS: =0.017). Exploratory machine learning analyses showed that depressive episodes and clinically relevant depressive symptoms were stable features for RHF risk identification but with weaker contributions than age, fasting blood glucose, and systolic blood pressure. CONCLUSIONS: In middle-aged and older adults, depressive symptoms are nonlinearly associated with RHF risks, which increased significantly when PHQ-9 score reached a clinically meaningful threshold. Major depressive episodes are also associated with increased RHF risks, and their temporal relationship and underlying mechanisms require further investigation in prospective studies.
Source: PubMed Central
Institutions: First Hospital of Lanzhou University, Lanzhou University
Language: Chinese
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7223817937