Work

[Role of Ddx56 gene associated with early-onset Parkinson disease in maintaining neural development and protecting against dopaminergic neuron apoptosis in zebrafish].

Year: 2026

Type: article

Abstract: OBJECTIVES: associated with the pathogenesis of early-onset Parkinson disease (PD) in maintaining survival of dopaminergic (DA) neurons during early development of zebrafish. METHODS: in early development of the nervous system. RESULTS: knockdown. These differentially expressed genes were significantly associated with neurodegenerative diseases, and their alterations resulted in changes in the level of oxidative phosphorylation. CONCLUSIONS: knockdown causes changes in PD- and DA-associated genes and induces apoptosis of DA neurons, suggesting its potential as a biomarker for early diagnosis of PD.

Source: PubMed Central

DOI: 10.12122/j.issn.1673-4254.2026.10.06

Authors: Qian Xu, Erqi Liu, Qiaofeng Zhang, Haixin Liu, Xinpei Lin, Yao Lin

Institution: Fujian University of Traditional Chinese Medicine

Language: Chinese

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7223835263