Work

Transendothelial Transport of Low-Density Lipoproteins in Atherosclerosis: Mechanisms of Activation and Possible Therapeutic Targets

Year: 2026

Type: article

Abstract: Despite advances in the prevention of cardiovascular events in recent decades, the risk of developing atherosclerosis and its complications remains a major challenge. One promising way to reduce this risk is to develop measures to inhibit the activated transport of low-density lipoproteins (LDL) through the endothelium, which is the initial stage of atherosclerosis. Recent research has provided some molecular details of the mechanism, including the roles of caveolin-1, LDL receptors, and certain motor proteins. This review summarizes data on recent advances in studying of LDL transendothelial transcytosis, focusing on its role in atherogenesis and its specificity for LDL, as well as on its regulation by hemodynamics, lipoproteins, cytokines, and metabolic factors. It also presents data on potential targets for inhibiting LDL transendothelial transport (TET) and the pros and cons of targeting these molecules. Further understanding of the mechanisms involved in LDL endothelial transcytosis and the development of targeted delivery systems for LDL TET inhibition may lead to improvements in the treatment of atherosclerosis and a better prevention of cardiovascular events.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms27219492

Authors: Dmitry A. Tanyanskiy, Alexander A Denisenko

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499

Funder: Ministry of Science and Higher Education of the Russian Federation