Work

Phenotyping of Arrhythmia-induced Cardiomyopathy: From Bench to Bedside and Back

Year: 2026

Type: review

Abstract: PURPOSE OF REVIEW: Arrhythmia-induced cardiomyopathy (AIC) is an increasingly recognized and potentially reversible cause or modifier of heart failure. This review summarizes experimental and clinical evidence with a focus on atrial fibrillation (AFib)-induced left ventricular systolic dysfunction. RECENT FINDINGS: Recent studies demonstrate that AIC extends beyond tachycardia alone and involves rhythm irregularity, loss of atrioventricular synchrony, altered calcium handling, oxidative stress, mitochondrial dysfunction and substrate vulnerability. Clinical trials demonstrate the superiority of rhythm control therapy by catheter ablation in patients with AFib and heart failure. Emerging data illustrate the importance of phenotyping of AIC according to myocardial substrate and individual ventricular response to AFib. AIC should be considered as a heterogeneous spectrum. Refined phenotyping may improve prediction of recovery and guide specific and individual therapy.

Source: Current Heart Failure Reports

DOI: 10.1007/s11897-026-00788-3

Authors: Thomas Körtl, Johannes Ruppert, Samuel Sossalla

Institutions: Justus-Liebig-Universität Gießen, Universitätsklinikum Gießen und Marburg, Kerckhoff Klinik, Cardio-Pulmonary Institute

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,490