Work

Jejunal B-Cell Non-Hodgkin Lymphoma Presenting with a Long Stenosing Lesion in an Adolescent: A Case Report

Year: 2026

Type: article

Abstract: Background: Jejunal involvement by pediatric B-cell non-Hodgkin lymphoma (NHL) can be difficult to diagnose when the lesion lies beyond conventional endoscopic reach. Case Presentation: A previously healthy 15-year-old boy presented with 2 weeks of postprandial vomiting, periumbilical pain, weight loss, peripheral lymphadenopathy, and a palpable abdominal mass. CT identified a large segment of jejunal thickening. Enteroscopy showed approximately 12 cm of ulcerated, friable stenosis with contact bleeding; the endoscope could traverse the affected segment. Biopsies demonstrated an atypical lymphoid infiltrate, and immunohistochemistry supported CD20-positive B-cell NHL without a definitive subtype. Persistent vomiting led to surgical exploration, which showed extensive abdominal disease considered unresectable. A palliative gastrojejunostomy was performed. Further molecular and formal staging investigations were not completed, and the patient died before planned chemotherapy. Conclusion: This case highlights the complementary diagnostic roles of CT and enteroscopy in jejunal lymphoma and the need to coordinate gastrointestinal palliation with prompt pathological and oncologic assessment. The available findings do not establish a specific lymphoma subtype or verifiable pediatric stage.

Source: Cancer Management and Research

DOI: 10.2147/cmar.s657567

Authors: Amara Salah Deeb, Ahmad Bishr Nasra, Jumana Alkaraa, Muhammad Alashkar, Ahmad Abd AlRahim Wassouf

Institution: Damascus University

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836