Work

[Gagp17 protein KSKK→KSQQ substitution and ΔKSKK deletion mutations promote HIV-1 release and Gagp17 maturation in HIV-1 CRF55_01B and CRF59_01B strains].

Year: 2026

Type: article

Abstract: OBJECTIVES: protein. METHODS: protein in the CRF59_01B and CRF55_01B strains were analyzed. HIV-1 mutant plasmids carrying the ΔKSKK deletion mutation and KSKK→KSQQ substitution mutation were constructed and their effects on viral release and maturation were evaluated. Spatiotemporal diffusion maps and key transmission chains of the two mutations were reconstructed using Bayesian discrete phylogeographic analysis. RESULTS: =0.918) and spread to China, then to the Americas, Europe, and Asia with Thailand and Australia as transmission hubs. CONCLUSIONS: protein characteristic of HIV-1 CRF55_01B and CRF59_01B strains result in enhanced viral replication and infectivity by modulating HIV-1 viral release and Gag protein cleavage maturation.

Source: PubMed Central

DOI: 10.12122/j.issn.1673-4254.2026.10.07