Work

Early Adrenaline Administration After Implementation of the Japanese Anaphylaxis Guideline 2014: A Single‐Center Retrospective Cohort Study

Year: 2026

Type: article

Abstract: ABSTRACT Background Early administration of adrenaline is the cornerstone of anaphylaxis treatment; however, delays in its administration remain common in clinical practice. The Japanese Anaphylaxis Guideline, published in 2014, aimed to standardize the diagnosis and early treatment of anaphylaxis, but its impact on clinical practice has not been fully evaluated. Aim To evaluate the impact of guideline implementation on time to adrenaline, incidence of biphasic reactions, and length of hospital stay (LOS). Methods This single‐center retrospective cohort study included 131 adult inpatients with anaphylaxis admitted between 2011 and 2022, categorized into a pre‐guideline group (Group A, n = 55) and a post‐guideline group (Group B, n = 76). Outcomes included time to adrenaline administration, incidence of biphasic reactions, and length of hospital stay (LOS). Results Following guideline implementation, the median time to adrenaline administration was shorter (6.0–5.0 min, p = 0.040). The incidence of biphasic reactions decreased from 16.5% to 6.6%, although the difference was not statistically significant ( p = 0.074). The median LOS decreased from 20.1 to 18.7 h, but this difference was also not statistically significant ( p = 0.080). Conclusions Guideline implementation was associated with significantly earlier adrenaline administration, indicating improved treatment processes, whereas reductions in biphasic reactions and length of hospital stay did not reach statistical significance.

Source: Acute Medicine & Surgery

DOI: 10.1002/ams2.70174

Authors: Kenji Kawai, Kazuhiko Omori, Tomohisa Nomura, Manabu Sugita, Yutaka Kondo

Institutions: Juntendo University, Juntendo University Nerima Hospital, Juntendo University Shizuoka Hospital, Juntendo University Hospital

Language: English

Topic: Food Allergy and Anaphylaxis Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250