[Jiaotaiwan improves lipid metabolism abnormalities in a mouse model of Alzheimer disease by regulating the AMPK signaling pathway].
Year: 2026
Type: article
Abstract: OBJECTIVES: ameliorates Alzheimer disease (AD) by regulating lipid metabolism via the AMPK pathway. METHODS: , AICAR, or both, and the intracellular lipid droplets, TG, NEFA, AMPK activity, and ACC expression were measured. RESULTS: combined with AICAR produced a synergistic effect for enhancing p-AMPK/AMPK expressions in the co-cultured cells. CONCLUSIONS: alleviates AD-related lipid deposition and dysregulation by activating AMPK and modulating the downstream lipogenic effectors, providing also protective effects on the blood-brain barrier and neural cells.
Source: PubMed Central
Authors: Yuqing Ruan, Can Cui, Jingzhe Li, Yan Wang, Xiu Wang
Institution: Wannan Medical College
Language: Chinese
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7224027680