Work

Diagnostic dilemma in a case of invasive mixed ductal lobular carcinoma of breast, a rare morphological subtype

Year: 2026

Type: article

Abstract: Invasive mixed ductal lobular carcinoma (mDLC) is a rare subtype (3-5%) of invasive breast carcinoma. It is composed of mixed population of both invasive breast carcinoma of no special type (IBC-NST) and invasive lobular carcinoma (ILC) components within an individual tumor. We are presenting a case report of a 56yrs female who presented with lump left breast. On initial core needle biopsy reported as a case of lobular carcinoma breast. The Modified radical mastectomy (MRM) specimen showed both the components of invasive ductal and lobular carcinoma. So it was reported as Invasive Mixed breast carcinoma of no special type (NST)(60%) and Invasive Lobular carcinoma (40%). We are presenting this case of invasive mixed ductal-lobular carcinoma as there was dilemma in the diagnosis due to limited sampling by core needle biopsy and limited data is available on this tumor subtype. Here, we are presenting this case highlighting and enumerating its clinical presentation, radiological, histopathology and immunohistochemical features.

Source: Annals of the National Academy of Medical Sciences (India)

DOI: 10.25259/anams_80_2025

Authors: Dimple Kapoor, Charu Nayyar, Vikas Garg, Cherry Bansal

Institution: Tantia University

Language: English

Topic: Breast Lesions and Carcinomas

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7224078078