Work

Response to "Interpreting Route, Dose, and Clinical Relevance in Perioperative Magnesium Sulfate After Total Knee Arthroplasty” [Response to Letter]

Year: 2026

Type: article

Abstract: We thank Gu and Chen for their thoughtful and constructive comments on our randomized controlled trial comparing intravenous, topical, and combined intravenous-plus-topical magnesium sulfate administration in patients undergoing total knee arthroplasty (TKA).1,2 We appreciate the opportunity to clarify several aspects of the study design, statistical analysis, and interpretation.We agree that the findings should be interpreted within the specific route-dose regimens evaluated and that the absence of a difference in the prespecified primary outcome should not be interpreted as formal equivalence.We address their comments below.

Source: Drug Design Development and Therapy

DOI: 10.2147/dddt.s660878

Authors: Qiuru Wang, Yinchan Wang, Jian Hu, Changjun Chen, Jing Yang, Pengde Kang

Institutions: Sichuan University, West China Hospital of Sichuan University, Shandong First Medical University

Language: English

Topic: Anesthesia and Pain Management

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836