Work

Predictive Accuracy of the Advanced-DiaRem Score for Type 2 Diabetes Remission After Sleeve Gastrectomy in a Persian Cohort

Year: 2026

Type: article

Abstract: Aims: This study evaluated the performance of the Advanced-DiaRem scoring system for predicting initial remission of type II diabetes mellitus (T2DM) after sleeve gastrectomy (SG) in the Persian population. Methods: A retrospective cohort study with cross-sectional telephone interviews was conducted, including adults with T2DM who underwent SG between 2016 and 2023. Baseline clinical, biochemical, and diabetes-related variables were collected, and Advanced-DiaRem scores were calculated. The primary outcome was initial T2DM remission, defined as initial physiological success rather than long-term, sustained remission. Receiver Operating Characteristic (ROC) curve analysis using Youden's Index evaluated model discrimination, and Decision Curve Analysis quantified clinical utility. Multivariable logistic regression identified independent predictors of initial remission. Results: Ninety-three patients (72.0% female) with a mean age of 49.1 ± 9.8 years were included, of whom 45.2% (95% CI: 34.9, 55.5) achieved initial remission. Remission was significantly associated with baseline HbA1c levels. The Advanced-DiaRem scoring system showed limited discriminatory performance (AUC 64.5%); the optimal cutoff <9 yielded 69% sensitivity, 59% specificity, 58% PPV, 70% NPV, 63% accuracy, LR+ of 1.68, and LR- of 0.53. Conclusion: The Advanced-DiaRem score showed limited accuracy in predicting initial T2DM remission after SG in this cohort. This study suggests that model recalibration or the development of population-specific prediction tools may improve predictive accuracy.

Source: Diabetes Metabolic Syndrome and Obesity

DOI: 10.2147/dmso.s589859

Authors: Yeganeh Karimi, Arash Abdollahi, Maziar Afshar, Ali Kabir

Institutions: Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Iran University of Medical Sciences, Kurdistan University of Medical Sciences

Language: English

Topic: Bariatric Surgery and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836