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Recent Advances in Site‐ and Stereocontrolled Selective Light‐Mediated Functionalizations of Monosaccharide Derivatives

Year: 2026

Type: article

Abstract: Recent advances in visible‐light photochemistry have profoundly transformed the selective functionalization of carbohydrates, offering straightforward alternatives to classical protecting‐group‐based strategies. This Review highlights the emergence of photochemical methods enabling site‐ and stereocontrolled editing of monosaccharide derivatives through radical‐mediated processes. Particular emphasis is placed on minimally protected and unprotected substrates, for which selective C─H activation, epimerization, bond‐forming reactions, and skeletal editing can now be achieved under mild conditions. Recent developments in photoredox catalysis involving hydrogen‐atom transfer, electron donor–acceptor complexes, and metallaphotoredox catalysis are discussed, together with the mechanistic principles governing regio‐ and stereoselectivity.

Source: ChemPhotoChem

DOI: 10.1002/cptc.70314

Authors: Corentin Lefebvre, Norbert Hoffmann

Institutions: Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources, Université de Picardie Jules Verne, Centre National de la Recherche Scientifique, Institut de Physique et Chimie des Matériaux de Strasbourg, Université de Strasbourg

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,030

OpenAlex ID: W7224098285

FWCI:

Cites: 193

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Related to: 10