Work

Synthesis, antitumor evaluation, and in silico investigation of pyridine-based pyrimidotriazine and triazolopyrimidine derivatives as potential EGFR-targeted anticancer agents

Year: 2026

Type: article

Abstract: ADME analysis revealed generally acceptable drug-likeness and pharmacokinetic characteristics, with compound-dependent variations in lipophilicity, gastrointestinal absorption, blood-brain barrier permeability, and P-glycoprotein recognition. Collectively, these findings identify compounds 6-8 as promising anticancer candidates, with compounds 6 and 8 representing potent and selective cell-based leads and compound 7 emerging as a promising EGFR-directed scaffold for further optimization. Furthermore, this work expands the chemical space of fused nitrogen heterocycles and provides a useful platform for the development of kinase-targeted anticancer agents.

Source: RSC Advances

DOI: 10.1039/d6ra07493f