Work

Synthesis of deuterated ALC-0315 for contrast variation SANS analysis of lipid nanoparticles

Year: 2026

Type: article

Abstract: . SANS study reveals that deuteration significantly increases the contrast match point (CMP) of ALC-0315, allowing for contrast-variation small angle neutron scattering measurements to selectively highlight internal LNP core-shell structure.

Source: RSC Advances

DOI: 10.1039/d6ra04368b

Authors: Hong-Hai Zhang, Wellington Leite, Sai Venkatesh Pingali, Brandon Nusser, Volker S. Urban, Hugh O'Neill

Institutions: Oak Ridge National Laboratory, Center for Nanophase Materials Sciences

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042