Work

Adolescent idiopathic scoliosis and comorbid anxiety and depression: advances in psychophysiological interaction mechanisms and integrated interventions

Year: 2026

Type: article

Abstract: Adolescent Idiopathic Scoliosis (AIS) is a common three-dimensional spinal deformity, and its comorbidity with psychological disorders such as anxiety and depression is increasingly attracting clinical and research attention. This narrative review aims to summarize the epidemiological characteristics of this comorbidity in AIS. It explores the complex underlying psychophysiological interaction mechanisms, including psychosocial stress, chronic pain, body image disturbance, and interconnected neuroendocrine and neuroimmune pathways. Based on this mechanistic understanding, the article further synthesizes and evaluates existing intervention strategies for this comorbid condition, encompassing psychological therapies, pharmacotherapy, physical rehabilitation, and emerging multidisciplinary integrated care models. Finally, the review outlines future research directions, with the goal of providing a theoretical foundation and a comprehensive management framework to improve the holistic physical and mental health outcomes for individuals with AIS.

Source: Frontiers in Psychiatry

DOI: 10.3389/fpsyt.2026.1878400

Authors: Zhaomeng Hou, Jiaojiao Wu, Hua Lu, Chaoqun Chen, Jing Wang, Tingliang Han

Institutions: Nanjing University of Chinese Medicine, Nanjing Medical University

Language: English

Topic: Scoliosis diagnosis and treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801