Work

An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors

Year: 2026

Type: article

Abstract: A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off a protein-degradation complex to allow cell proliferation to start, with implications for WEE1 inhibitors currently in trials for cancer treatments.

Source: Nature

DOI: 10.1038/d41586-026-03288-5

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $12,690

OpenAlex ID: W7224121521

FWCI:

Cites: 5

Cited by:

Related to: 10