Work

NTRK1 ‐Rearranged Cutaneous Non‐Langerhans Cell Histiocytosis With Durable Response to TRK Inhibitor in a Patient With Primary Myelofibrosis

Year: 2026

Type: article

Abstract: Non-Langerhans cell histiocytoses (non-LCH) are heterogeneous histiocytic neoplasms driven by recurrent kinase pathway activation. NTRK1 fusions have recently been identified as recurrent, actionable alterations as drivers of xanthogranulomatous proliferations. We report a 62-year-old man with primary myelofibrosis (PMF) who developed multifocal, symptomatic cutaneous non-LCH harboring an IRF2BP2::NTRK1 fusion. The cutaneous eruption was refractory to ruxolitinib but showed complete response to larotrectinib, with successful rechallenge after treatment discontinuation. This case illustrates targeted therapy in concurrent myeloid and histiocytic neoplasms and expands the clinical spectrum of NTRK1-rearranged histiocytosis.

Source: Journal of Cutaneous Pathology

DOI: 10.1111/cup.70224

Authors: Scott Kuan‐Wen Wang, Dean George, Nan Ring, Nicholas Dainiak, Leslie Robinson‐Bostom

Institutions: Hartford Hospital, Brown University

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7224128671

FWCI:

Cites: 10

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Related to: 10