Work

A LRRC37A2 single nucleotide variant is associated with emphysema in Japanese patients with rheumatoid arthritis

Year: 2026

Type: article

Study design: Observational Study

Abstract: Objective Extra-articular manifestations commonly complicate rheumatoid arthritis (RA) and include chronic lung diseases (CLD), for example, interstitial lung disease or emphysema (EMP). These confer a poor prognosis. Genetic studies of idiopathic pulmonary fibrosis (IPF) or EMP were conducted. However, there are limited genetic studies on EMP in RA. We examined whether a single nucleotide variant associated with susceptibility to IPF was associated to EMP in Japanese RA patients. Methods rs199526 [C/G] genotyping of LRRC37A2 in samples from 88 RA patients with EMP and 425 RA lacking CLD was conducted. Results LRRC37A2 rs199526C was significantly associated to EMP in RA according to an allele model (p = 0.0083, odds ratio [OR] 1.72, 95% confidence interval [CI] 1.14-2.59) or recessive model for major alleles (p = 0.0139, OR 1.82, 95% CI 1.13-2.94), although it was protectively associated against IPF in European populations. Multiple logistic regression analyses revealed an independent association with age, Steinbrocker stage, and Steinbrocker class. An association between LRRC37A2 rs199526 and RA per se was detected. Conclusion An association between rs199526 and EMP was noted in Japanese RA. Differential roles of the single nucleotide variant between EMP in RA and IPF were suggested.

Source: Rheumatology Advances in Practice

DOI: 10.1093/rap/rkag133

Authors: Takashi Higuchi, Shomi Oka, Kota Shimada, Shinichiro Tsunoda, Satoshi Ito, Misuzu Fujimori, Tadashi Nakamura, Michita Suzuki, Koichiro Saisho, Satoshi Shinohara, Toshihiro Matsui, Kiyoshi Migita, Shouhei Nagaoka, Shigeto Tohma, Kenji Itoh, Hiroshi Furukawa

Institutions: Tokyo National Hospital, National Sagamihara Hospital, Tokyo Metropolitan Tama Medical Center, Hyogo Medical University, Sumitomo Hospital, Niigata Rheumatic Center, Himeji Medical Center, Sakurajyuji Hospital, Nagoya Medical Center, National Hospital Organization Miyakonojo Medical Center, Fukushima Medical University, Nagasaki Medical Center, Yokohama Minami Kyosai Hospital

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,974

Funders: Bristol-Myers Squibb, Pfizer, Takeda Pharmaceuticals U.S.A., Japan Research Foundation for Clinical Pharmacology, Nakatomi Foundation, Mitsui Sumitomo Insurance Welfare Foundation, Abbott Japan, Asahi Kasei Pharma Corporation, Dainippon Sumitomo Pharma, Eisai, Astellas Pharma, Daiwa Securities Health Foundation, Teijin Pharma, Mitsubishi Tanabe Pharma Corporation, Ono Pharmaceutical, Pfizer Japan, Chugai Pharmaceutical, Japan Society for the Promotion of Science, Daiichi Sankyo Europe

Awards: Genetic factors of interstitial lung disease associated with polymyositis and dermatomyositis., Genetic Association Study on HLA with Interstitial Lung Diseases in Rheumatoid Arthritis Patients., Elucidation of the genetic factors and the mechanisms of adverse effects by anti-rheumatic drugs., The regulation of the expression of SH2D1A gene in systemic lupus erythematosus., The important roles of a common protective allele HLA-DRB1*13:02 in collagen diseases.

OpenAlex ID: W7224129012

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