Work

Tricin‐Loaded Liposomes as a Passive Targeting Nanodelivery System for Enhanced Gastric Cancer Therapy

Year: 2026

Type: article

Abstract: ABSTRACT Gastric cancer (GC) has a poor prognosis. Chemotherapy causes severe systemic toxicity, and only a small subset of patients benefits from HER2/PD‑L1‑targeted therapies. Tricin (TRI), a natural flavonoid with anti‑GC activity, is limited by poor water solubility and low bioavailability. This study aimed to construct TRI‑loaded liposomes (TRI@Lips) to overcome these drawbacks and evaluate their antitumor performance. TRI@Lips were prepared by thin‑film hydration and characterized by DLS, FTIR, TEM, and release assays. Cytotoxicity, cellular uptake, in vivo tumor distribution, antitumor efficacy, and biosafety were examined using SGC‑7901/GSE‑1 cells, fluorescent tracers, and xenograft mice. TRI@Lips showed uniform spherical morphology (average size: 217.5 nm, PDI: 0.198, zeta potential: −8.84 mV), with 87.3% encapsulation efficiency, 9.2% drug loading, and 67.2% release at pH 5.0 within 72 h. The IC 50 against SGC‑7901 cells was 3.4 µg/mL, with minimal toxicity to GSE‑1 cells. EPR‑mediated tumor accumulation was confirmed. In vivo, TRI@Lips reduced tumor weight to 0.3 g and Ki67‑positive rate to 11.6%, without major organ injury. TRI@Lips enhance TRI solubility, cellular uptake, and tumor accumulation, representing a low‑toxic passive‑targeting candidate for GC treatment.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.71830

Authors: Baiji Cui, Hongmei Zhang, Hao Wu, Libo Wang, Tianyi Zhang, Zengjun Guo

Institutions: Jilin Medical University, Xi'an Jiaotong University, People 's Hospital of Jilin Province

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,880