Work

Optimization of the intramolecular cyclization to form the clozapine lactam intermediate under continuous-flow conditions and elucidation of the H 2 SO 4 -catalyzed mechanism by DFT

Year: 2026

Type: article

Abstract: Continuous-flow cyclization on a Vapourtec E-Series system afforded the clozapine lactam intermediate in 60 min at 130 °C with 3% H 2 SO 4 , achieving 90.87 ± 1.22% yield. DFT calculations identified two plausible reaction pathways.

Source: RSC Advances

DOI: 10.1039/d6ra09280b

Authors: Nguyen Thi Kim Anh, Tran Thi Yen, Nguyen Ngoc Chien, Ngo Quoc Anh, Nguyen Thi Thuy Hang

Institutions: Hanoi University of Pharmacy, Viện Hóa học, Hanoi University of Industry, Vietnam Academy of Science and Technology, Ton Duc Thang University

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Fluid Flow and Transfer Processes

Field: Chemical Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

OpenAlex ID: W7224167697

FWCI:

Cites: 27

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Related to: 10