Year: 2026
Type: article
Abstract: chronic rhinosinusitis | granulomatosis with Polyangiitis | rituximab | septal perforation MethodsThis retrospective cohort study was conducted using the TriNetX Research Network, a federated electronic health record platform aggregating de-identified data from participating health systems.Patients with a diagnosis of GPA between January 1, 2015 and December 31, 2025 and first dose of rituximab within 26 weeks of their diagnosis were included.Patients that received rituximab prior to diagnosis date, received cyclophosphamide between Key Points• Delayed rituximab after GPA diagnosis correlated with higher risk of septal perforation and CRS.• Early initiation corresponded with 3-year absolute risk reductions of 6%-10%.• Rituximab initiation within 2 weeks of diagnosis is associated with lower risk of irreversible sinonasal damage.diagnosis and rituximab initiation, or had life-threatening disease at diagnosis were excluded.Patients were stratified by time from diagnosis to rituximab initiation: less than 2 weeks (reference group), 2 to 6 weeks, and 6 to 12 weeks.Primary outcomes were septal perforation and CRS over a 3-year period from GPA diagnosis.Outcomes were identified using a combination of ICD-10-CM and CPT/ICD-10-PCS procedure codes (Table S1 ).Patients with a documented outcome prior to GPA diagnosis date were excluded.Cox proportional hazards regression compared each delayed timing group to the reference group with a 3-year observation window from GPA diagnosis.Results are reported as hazard ratios with 95% confidence intervals and two-sided p -values.Absolute risks were calculated within propensity score matched cohorts to provide clinically interpretable estimates of outcome Ismail M. Khaderi and
DOI: 10.1002/alr.70305
Authors: Ismail M. Khaderi, Nathan R. Barefoot, James M. Hardy, Nithya P. Gurumurthy, Jack Womble, Sean A. Celli, David J. Dillard, Kosuke Tochigi, Priya J. Desai, Elena Quinonez Del Cid, Katrina Bootes, Cristine Klatt‐Cromwell, Jackson Vuncannon, Charles S. Ebert, Brent A. Senior, Adam J. Kimple, Brian D. Thorp
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7224356525