Outcomes in Studies for Individuals Receiving Home Mechanical Ventilation: Scoping Review
Year: 2026
Type: article
Study design: Systematic Review
Abstract: Background Home mechanical ventilation (HMV) is a life-sustaining therapy for individuals with chronic respiratory failure. Despite a high morbidity and mortality of patients using HMV, few clinical trials inform practice. HMV-related research is impacted by the absence of a core outcome set (COS). This scoping review informs the development of a COS to be reported in interventional studies for individuals requiring HMV. Methods We conducted a scoping review including interventional and cohort studies recruiting adults and children receiving HMV. We searched six databases in March 2026, and conducted citation tracking of relevant studies. Study screening and data extraction were conducted independently in duplicate. We categorised outcomes using the Core Outcome Measures in Effectiveness Trials (COMET) 38-domain taxonomy, and assessed reporting quality using established criteria. Results Of 21 467 records screened, 287 studies were included: 78% adult, 18% paediatric, and 4% mixed populations. Studies evaluated HMV initiation (56%), patient interventions (31%), caregiver interventions (11%); or a combination of components (2%). We identified 71 distinct primary and 100 distinct secondary outcomes representing all COMET core areas. Primary outcomes were frequently in the respiratory, hospital, and mortality/survival domains, while respiratory, delivery of care, and global quality of life outcomes were predominant among secondary outcomes. Outcome reporting quality was high in 68% of studies. Conclusion Outcome selection in HMV studies is highly variable, supporting the need for a COS to improve consistency of future research informing clinical decision-making and policy.
Source: ERJ Open Research
Authors: Reshma Amin, Samantha Mekhuri, Joseph S. Munn, Alba Torrent-Vernetta, Lily Johnson, Kasthuri Satgunanathan, Munazzah Ambreen, Jessie Cunningham, Laura Istanboulian, Cheryl Laratta, Kevan Mehta, Jalal Moolji, The Thanh Diem Nguyen, Aditi Shah, Aaron St. Laurent, Anu Tandon, Thilipan Thaventhiran, Marie Wright, Lena Xiao, Danielle Adam, Veronique Adam, Tareq Alabdoulsalam, Kali Barrett, David Berlowitz, Florence Birru, Francine Buchanan, Ron Butler, Mathew Cherian, Jackie Chiang, Nisha Cithiravel, Maria Codesal, Craig Dale, Marielena Dibartolo, Refika Ersu, Haley Fishman, Andrea Gershon, Eleni Giannouli, Dean Hummel, Marta Kaminska, Sherri Katz, Tetyana Kendzerska, David Leasa, Audrey Lim, Andrea Loewen, Joanna Maclean, Dimas Mateos, Irvin Mayers, Douglas McKim, Sujay Mondal, Indra Narang, Mika Nonoyama, Colleen O'Connell, Homira Osman, Regina Pizzuti, Jody Platt, Jean-Paul Praud, Tim Ramsay, Jenny Shi, Kevin Solverson, Faiza Syed, Tuyen Tran, Robert Varadi, David Wensley, Lisa Wolfe, Susi Vander Wyk, David Zielinski, Louise Rose
Institutions: Hospital for Sick Children, Vall d'Hebron Hospital Universitari, University of Toronto, University of Alberta, University of Alberta Hospital, McMaster Children's Hospital, Centre Hospitalier Universitaire Sainte-Justine, University of British Columbia, London Health Sciences Centre, Sunnybrook Health Science Centre, Imperial College Healthcare NHS Trust, BC Children's Hospital, Izaak Walton Killam Health Centre, McGill University Health Centre, University of Manitoba, Institute for Breathing and Sleep, Austin Health, Sickkids Research Institute, McGill University, Children's Hospital of Eastern Ontario, Ottawa Hospital, Hamilton Health Sciences, McMaster University, Alberta Health Services, Dalhousie University, Muscular Dystrophy Canada, Alberta Children's Hospital, Université de Sherbrooke, Ottawa Hospital Research Institute, University of Calgary, West Park Healthcare Centre, Northwestern University, King's College London
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $808
OpenAlex ID: W7214513385