Work

Formal Total Synthesis of (±)‐Carexane L Enabled by a PPA‐Mediated Fragmentation–Cyclization Cascade and Heck Coupling

Year: 2026

Type: article

Abstract: ABSTRACT We present a succinct formal total synthesis of the rearranged aromatic sesquiterpene (±)‐carexane L, an indanone‐based natural product derived from the roots of Carex distachya Desf., a species indigenous to the Mediterranean maquis, commencing from benzoic acid. The synthesis strategically employs a combination of one‐pot polyphosphoric acid (PPA)‐mediated cyclization and Heck cross‐coupling as pivotal reactions.

Source: ChemistrySelect

DOI: 10.1002/slct.75030

Authors: Reddigunta Ramesh Babu, Amit Kumar Srivastava, Yogendra Kumar Mahato, Madhava Muttineni

Institution: Delaware County Community College

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W7224552330

FWCI:

Cites: 18

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Related to: 10