Work

Application of Bifunctional Togni’s Reagent in Photoredox‐Catalyzed Oxytrifluoromethylation of Alkenes

Year: 2026

Type: article

Abstract: We report a radical‐based protocol for the photoredox‐catalyzed oxytrifluoromethylation of alkenes with Togni’s reagent. This strategy provides efficient access to a broad array of CF 3 ‐containing esters and is also applicable to late‐stage functionalization of drug molecules under mild conditions. Moreover, conversion of the resulting CF 3 ‐functionalized esters to other valuable building blocks is also achieved. Mechanistic investigations reveal that Togni’s reagent acts as both a trifluoromethyl and an acyloxy group. Consequently, the difunctionalization reaction can proceed without any external nucleophiles, offering high atom economy.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70844

Authors: Xiaoyu Wang, Ronghui Zhang, Yuyang Xue, Yichen Tao, Sixu Yang, Lin Tang

Institution: Xinyang Normal University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

OpenAlex ID: W7224552626

FWCI:

Cites: 56

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Related to: 10